Graft versus host reaction. An ultrastructural study

Cytotoxicity in Graft-versus-host Reaction

Under in vitro conditions spleen cells from nonirradiated F(1) hybrids, in which a (graft-vs.-host) (GVH) reaction had been induced with lymphoid cells of parental origin, lysed nonspecifically target cells, i.e., cells syngeneic or allogeneic to the parental genotypes. Furthermore, tumor cells exposed in vitro to spleen cells of F(1) hybrid mice undergoing GVH reaction had markedly decreased a...

Graft-versus-host disease or graft-versus-host-like syndrome.

Bone marrow transplantation and graft-versus-host reaction.

Gribben JG, Freedman AS, Neuberg D, et al. Immunologic purging of marrowassessed by PCRbefore autologous bone marrowtransplantation for B-cell lymphoma. N Engl J Med 325: 1525, 1991. HamonMD, Prentice HG, Gottlieb DJ, et al. Immunotherapy with interleukin 2 after ABMTin AML.Bone Marrow Transplant ll: 399, 1993. Yanai N, Sekine C, Yagita H, Obinata M, Roles for integrin vary late activation anti...

Malignant lymphoma and amyloidosis following graft-versus-host reaction.

Persistent stimulation of immunocompetent cells, such as histocompatibility reactions, may be one of the causes of neoplastic proliferation of lymphoreticular tissues. In the present studies, the graft-versus-host reaction was induced in 18week-old male ( C 57 Bl/6] x DBA/2 J )F1 mice · by two or four weekly intraperitoneal injections of approximately 80 x 106 male C 57 Bl/6 J or C 57 Bl/Na mou...

Enhancement of tumor growth by graft-versus-host reaction.

A graft-versus-host reaction was induced in (BALB/c x C5 7BL/6)F(1) mice by intravenous injection of BALB/c spleen cells. Six days later, the mice received subcutaneous grafts of a chemically induced BALB/c sarcoma. The growth of the tumor grafts was accelerated.